Biomarkers & Bioinformatics

Enabling Platform

Research Leaders:

befus 12-Gordon 12-McNagny
Dr. Dean Befus, Professor, Division of Pulmonary Medicine, Department of Medicine, University of Alberta; Astra-Zeneca Canada Inc., Chair in Asthma Research Dr. John Gordon, Professor, Division of Respirology, Critical Care & Sleep Medicine, Department of Medicine, University of Saskatchewan Dr. Kelly McNagny, Professor, Department of Medical Genetics, The University of British Columbia

Strategic Focus:

Biomarkers and Bioinformatics researchers focus on the discovery, development and commercialization of diagnostic tests and treatments for asthma and allergies, and manage, analyze and interpret data in order to accelerate advances in patient care, and personalized and public health.

Biomarkers and Bioinformatics Backgrounder
Biomarkers and Bioinformatics Publications

 

Projects:

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ProjectTermInvestigators

Neuroendocrine regulation of allergic reactions in animal models: Translation to humans

2007 - 2009

MacQueen, Glenda

Neuroimmune interactions: a partnership in drug development and translational research

2009 - 2012

Befus, Dean; Halloran, Philip; Hamid, Qutayba; Kollmann, Tobias; Mathison, Ronald; O’Byrne, Paul

Non-invasive diagnosis: Metabolics for the various phenotypes of asthma (formerly: Diagnosing the Various Phenotypes of Asthma: The Use of Urine NMR) (Success Stories profile)

2007 - 2009

Adamko, Darryl; Becker, Allan; Marrie, Tom; Mayers, Irvin; Moqbel, Redwan; Rowe, Brian; Sykes, Brian; Vethanayagam, Dilini

Perinatal stress and programming of allergic responses

2007 - 2009

Arck, Petra; Bienenstock, John; Forsythe, Paul; Heinrich, Joachim; Inman, Mark; Pincus, Maike; Wahn, Ulrich

Regulation of lung mucosal immune responses by heterologous exposure to multiple infectious and allergic agents

2006 - 2009

Brown, Earl; Coyle, Anthony; Gauldie, Jack; Hogaboam, Cory; Inman, Mark; Jordana, Manel; Stampfli, Martin; Xing, Zhou

Role of fibrocytes as biomarkers of airway remodelling in asthma: A proof of concept

2010 - 2012

Boulet, Louis-Philippe; Chakir, Jamila

Role of mast cells and eosinophils in allergic inflammationand fibrosis of the lung

2006 - 2009

Kelly, Margaret; Kubes, Paul; McNagny, Kelly; Mody, Chris

Study of the pathogenesis and reversibility of airway damage and repair during chronic mucosal immune responses to environmental allergies (Success Stories profile)

2006 - 2009

Hamid, Qutayba; Lavoie, Jean-Pierre; Lussier, Jacques; Martin, James

The distribution and function of FceR1 on nerves

2009 - 2012

Befus, Dean; Bienenstock, John; Forsythe, Paul; McNagny, Kelly; Rivera, Juan; Waserman, Susan

The link between upper and lower airway inflammation (Success Stories profile)

2005 - 2006

Boulet, Louis-Philippe; Denburg, Judah; Keith, Paul

Thymic Stromal Lymphopoitin-induced Cord Blood Hemopoietic Progenitors: Biomarkers for the Development of Atopy and Asthma

2008 - 2010

Denburg, Judah; Gauvreau, Gail; O’Byrne, Paul

TLR function in human neonates

2005 - 2006

Becker, Allan; HayGlass, Kent; Kozyrskyj, Anita; Marshall, Aaron; Morris, Maggie; Rola-Pleszczynski, Marek

Urine NMR-based Metabolomics for Asthma Diagnosis (Success Stories profile)

2012 - 2014

Adamko, Darryl; Busse, William; Gauvreau, Gail; Rowe, Brian; Sykes, Brian; Vliagoftis, Harissios

Urine NMR-Metabolomics for Asthma Diagnosis: Respirlyte (Patent) (Success Stories profile)

2013 - 2014

Adamko, Darryl

Vaccines for asthma & allergies – a bacterial immune-prophylactic and therapeutic approach (Success Stories profile)

2009 - 2012

Gordon, John; Kollmann, Tobias; Larché, Mark; Mazer, Bruce; McNagny, Kelly

A network biology approach to allergy requires annotated database of molecular interaction (Success Stories profile)

2012 - 2014

Brinkman, Fiona; Lynn, David

Allergic Asthma functional & Pharmaco-genomics for Early and Late Phase Response Biomarkers

2012 - 2014

Gauvreau, Gail; McManus, Bruce; Tebbutt, Scott

Antenatal steroid therapy for fetal lung maturation: Is there an association with childhood asthma (Success Stories profile)

2005 - 2006

Beyene, Joseph; Mustard, Cameron; To, Teresa

Biomarkers of a Sympathetic Anti-inflammatory Pathway, Neuro-regulation of Sympathetic Anti-inflammatory Activity

2012 - 2014

Befus, Dean; Boulet, Louis-Philippe; Davies, Kelvin Paul; Gauvreau, Gail; O’Byrne, Paul; Ritz, Thomas

Blocking Human CD34 Expression as a Therapeutic for Mucosal Inflammatory Disease

2009 - 2011

McNagny, Kelly