Biomarkers & Bioinformatics

Enabling Platform

Research Leaders:

befus 12-Gordon 12-McNagny
Dr. Dean Befus, Professor, Division of Pulmonary Medicine, Department of Medicine, University of Alberta; Astra-Zeneca Canada Inc., Chair in Asthma Research Dr. John Gordon, Professor, Division of Respirology, Critical Care & Sleep Medicine, Department of Medicine, University of Saskatchewan Dr. Kelly McNagny, Professor, Department of Medical Genetics, The University of British Columbia

Strategic Focus:

Biomarkers and Bioinformatics researchers focus on the discovery, development and commercialization of diagnostic tests and treatments for asthma and allergies, and manage, analyze and interpret data in order to accelerate advances in patient care, and personalized and public health.

Biomarkers and Bioinformatics Backgrounder
Biomarkers and Bioinformatics Publications

 

Projects:

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ProjectTermInvestigators

Cross-talk between Airway Epithelial and CD34 Hemopoietic Progenitor Cells Mediated by TSLP and IL-33 in Asthmatic and Normal Individuals

2008 - 2010

Delespesse, Guy

Develop and implement an allergen-gene environment database resource (Success Stories profile)

2007 - 2009

Daley, Denise

Development of an Adaptive Immune Phenotyping Monitoring Platform (Annual Report story: Discovering biomarkers of allergic disease)

2007 - 2009

Boulet, Louis-Philippe; Cyr, Michael; Keith, Paul; Kollmann, Tobias; Larché, Mark; O’Byrne, Paul; Ohayon, Jason; Sekaly, Rafick-Pierre; Turvey, Stuart; Waserman, Susan

Developmental plasticity and fetal programming of asthma in mice

2009 - 2012

Arck, Petra; Forsythe, Paul; Kobor, Michael; Petronis, Arturas; Pincus, Maike; Vliagoftis, Harissios; Wahn, Ulrich

Effects of probiotics on murine model of asthma (Success Stories profile)

2005 - 2006

Bienenstock, John; Forsythe, Paul

Environmental impact on the epithelial immune barrier in asthma (Success Stories profile)

2006 - 2008

Bai, Tony; Dorscheid, Del; Hegele, Richard; Knight, Darryl; van Eeden, Stephan

Environmental impact, inflammation and the role of IL-13 receptor a2

2009 - 2012

Agnes, George; Dorscheid, Del; Eades, Joshua; Gauvreau, Gail; Hegele, Richard; Inman, Mark; Mazer, Bruce; Pfeifer, Tom; Sandford, Andrew; Scott, James; Scott, Jeremy; Silverman, Frances

Functional TSLP genomics in vitro and ex vivo: human epithelial cell production of TSLP in relation to asthma development

2008 - 2010

Bosse, Yohan; Daley, Denise; Knight, Darryl; Laprise, Catherine; Paré, Peter; Sandford, Andrew

Further Development of the Genapha Website:An AllerGen Genomic database resource (Success Stories profile)

2010 - 2011

Daley, Denise

Genome-wide Association Results

2012 - 2014

Becker, Allan; Daley, Denise; Demanais, Florence; Kozyrskyj, Anita; Paré, Peter; Sandford, Andrew

Hemopoietic stem cell biomarkers in the diagnosis and prediction of allergic inflammation and disease (Success Stories profile)

2009 - 2012

Atkinson, Stephanie; Berthelet, Sharon; Deeley, Roger; Delespesse, Guy; Denburg, Judah; Djandji, Michel; Ellis, Anne; Gauvreau, Gail; Howard, Lisa; Larché, Mark; McCans, John; McNagny, Kelly; Murphy, Timothy; O’Byrne, Paul; Prescott, Susan; Storer, Andrew; Teo, Koon

Hemopoietic stem cell biomarkers in the diagnosis and prediction of allergic inflammation and disease: STEM (Stem cell Team for Emerging Markers)

2012 - 2016

Denburg, Judah; Ellis, Anne

Hemopoietic stem cells as biomarkers of atopy, airways inflammation, and sources of ‘epigenetic’ memory

2007 - 2009

Ackerman, Steven; Atkinson, Stephanie; Cyr, Michael; Denburg, Judah; Foster, Warren; Holt, Patrick; Prescott, Susan; Sly, Peter; Teo, Koon

Host environment interaction: Educating TLR-4+lymphocytes in childhood

2005 - 2006

Hamid, Qutayba; Martin, James; Mazer, Bruce

IDO, glutamate receptors and allergic inflammation

2005 - 2006

Duszyk, Marek; Ghahary, Aziz; Halayko, Andrew; Moqbel, Redwan

Intracellular Cytokine Production

2007 - 2009

Hamid, Qutayba; Mazer, Bruce

Metabolomics

2009 - 2012

Adamko, Darryl; Becker, Allan; Custovic, Adnan; Ellis, Anne; Gauvreau, Gail; Mayers, Irvin; Moqbel, Redwan; Ratz, Jodan; Rowe, Brian; Sykes, Brian; Taylor, Neil; Vethanayagam, Dilini

Modulation of exocytosis in allergic inflammation

2005 - 2006

Dawny, Gregory; Eitzen, Gary; Lacy, Paige

Molecular interactions and ontologies for allergy and asthma (Annual Report story: Mapping molecular interactions of allergic disease)

2011 - 2013

Brinkman, Fiona

Neuroendocrine Regulation of Allergic Inflammation: Translational Studies (Success Stories profile)

2007 - 2009

Befus, Dean; Davison, Joe; Mathison, Ronald; Metwally, Essam; O’Byrne, Paul; Wilkinson, Mark