CIC Publications

Refereed Journal Articles

The database below lists the refereed journal articles that have emerged from the Canadian Investigators Collaborative (CIC) Legacy Project.

The database can be sorted and/or searched by different data fields. When searching by author, use last name only.


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Author(s)YearTitleJournal
Lim HF, Ho T, Kjarsgaard M, Efthimiadis A, Yamamurah D, Nair P. 2018

Sputum plug selection under inverted microscopy improves microbial identification during exacerbations of airway diseases

Respiratory Medicine

Svenningsen S, Eddy RL, Lim HF, Cox PG, Nair P, Parraga G 2018

Sputum Eosinophilia and Magnetic Resonance Imaging Ventilation Heterogeneity in Severe Asthma

American Journal of Respiratory and Critical Care Medicine

Sehmi R, Lim HF, Mukherjee M, Huang C, Radford K, Newbold P, Boulet LP, Dorscheid D, Martin JG, Nair P. 2018

Benralizumab attenuates airway eosinophilia in prednisone-dependent asthma

Journal of Allergy and Clinical Immunology

Kim LH, Plaza K, Thomas SR, Draijer C, Radford K, Peters-Golden M, Mukherjee M, Nair P 2018

Endogenous peroxidases in sputum interfere with horse-radish peroxidase-based ELISAs

Journal of Immunological Methods

Gauvreau GM, FitzGerald JM, Boulet L-P, Watson R, Hui L, Villeneuve H, Scime T, Schlatman A, Obminski C, Kum J, Boehme S, Ly TW, Bacon K, O'Byrne PM 2018

The Effects of a CCR3 Inhibitor, AXP1275, on Allergen-Induced Airway Responses in Adults with Mild-to Moderate Atopic Asthma

Clinical & Experimental Allergy

Singh A, Shannon CP, Kim YW, Yang CX, Balshaw R, Cohen Freue GV, Gauvreau GM, FitzGerald JM, Boulet L-P, O'Byrne PM, Tebbutt SJ 2018

Novel blood-based transcriptional biomarker panels predict the late phase asthmatic response

American Journal of Respiratory and Critical Care Medicine

Tang W, Smith SG, Du W, Gugilla A, Du J, Oliveria JP, Howie K, Salter BM, Gauvreau GM, O'Byrne PM, Sehmi R 2018

Interleukin-25 and eosinophils progenitor cell mobilization in allergic asthma

Clinical Translational Allergy

Al-Sajee D, Oliveria JP, Sehmi R, Gauvreau GM 2018

Antialarmins for treatment of asthma: future perspectives

Current Opinion in Pulmonary Medicine

Revez JA, Killian KJ, O'Byrne PM, Boulet LP, Upham JW, Gauvreau GM, Ferreira MAR 2018

Sputum cytology during late-phase responses to inhalation challenge with different allergens

Allergy

Salter BMA, Smith SG, Mukherjee M, Plante S, Krisna S, Nusca G, Oliveria JP, Irshad A, Gauvreau GM, Chakir J, Nair P, Sehmi R 2018

Human Bronchial Epithelial Cell-derived Factors from Severe Asthmatic Subjects Stimulate Eosinophil Differentiation

American Journal of Respiratory and Critical Care Medicine

Lim HF, Nair P. 2018

Airway inflammation and biomarkers in asthma

Seminars in Respiratory Critical Care Medicine

Son K, Mukherjee M, McIntyre BAS, Eguez JC, Radford K, LaVigne N, Ethier C, Davoine F, Janssen L, Lacy P, Nair P 2017

Improved recovery of functionally active eosinophils and neutrophils using novel immunomagnetic technology

Journal of Immunological Methods

Nair P, Wenzel S, Rabe KF, Bourdin A, Lugogo NL, Kuna P, Barker P, Sproule S, Ponnarambil S, Goldman M 2017

Oral Glucocorticoid-Sparing effect of Benralizumab in Severe asthma

New England Journal of Medicine

Lawson JA, Rennie DC, Cockcroft DW, Dyck R, Afanasieva A, Oluwole O, Afsana J. 2017

Childhood asthma, asthma severity indicators, and related conditions along an urban-rural gradient: a cross-sectional study

BMC Pulmonary Medicine

Mukherjee M, Lim HF, Thomas S, Miller D, Kjarsgaard M, Tan B, Sehmi R, Khalidi N, Nair P. 2017

Airway autoimmune responses in severe eosinophilic asthma following low-dose Mepolizumab therapy

Allergy, Asthma & Clinical Immunology

Mukherjee M, Svenningsen S, Nair P. 2017

Glucocortiosteroid subsensitivity and asthma severity

Current Opinion in Pulmonary Medicine

Lok SD, Davis BE, Cockcroft DW 2017

Prevalence of allergen sensitization in 1000 adults in Saskatchewan

Allergy, Asthma & Clinical Immunology

Nair P, Martin JG, Cockcroft DC, Dolovich M, Lemiere C, Boulet LP, O'Byrne PM 2017

Airway Hyperresponsiveness in Asthma: Measurement and Clinical Relevance

Journal of Allergy and Clinical Immunology: In Practice

Oluwole O, Kirychuk SP, Lawson JA, Karunanayake C, Cockcroft DW, Willson PJ, Senthilselvan A, Rennie DC. 2017

Indoor mold levels and current asthma among school-aged children in Saskatchewan, Canada

Indoor Air

Zago M, Sheridan JA, Traboulsi H, Hecht E, Zhang Y, Matthews J, Nair P, Eidelman D, Baglole CJ. 2017

Low levels of the AhR in chronic obstructive pulmonary disease (COPD)-derived lung cells increases COX-2 protein by altering mRNA stability

PLoS ONE

Mukherjee M, Bulir D, Radford K, Kjarsgaard M, Huang C, Jacobsen E, Ochkur S, Lee J, Lacy P, Mahony J, Nair P. 2017

Sputum autoantibodies in severe eosinophilic asthma

Journal of Allergy and Clinical Immunology

O'Byrne PM, FitzGerald JM, Zhong N et al. 2017

The SYGMA programme of phase 3 trials to evaluate the efficacy and safety of budesonide/formoterol given as needed in mild asthma: study protocols for two randomised controlled trials

Trials

Katial R, Bensch GW, Busse WW, Chipps BE, Denson JL, Gerber AN, Jacobs JS, Kraft M, Martin RJ, Nair P, Wechsler ME. 2017

Changing Paradigms in the Treatment of Severe Asthma: The Role of Biologic Therapies

Journal of Allergy and Clinical Immunology: In Practice

Mukherjee M, Lim HF, Thomas S, Miller D, Kjarsgaard M, Tan B, Sehmi R, Khalidi N, Nair P. 2017

Airway autoimmune responses in severe eosinophilic asthma following low-dose Mepolizumab therapy

Allergy, Asthma & Immunology Research

Svenningsen S, Nair P 2017

Asthma Endotypes and an Overview of Targeted Therapy for Asthma

Frontiers in Medicine

Blais C, Cockcroft DW, Veilleux J, Boulay ME, Boulet L-P, Gauvreau GM, Scime TX, Watson RM, O’Byrne PM, Davis BE 2017

Methacholine challenge: comparison of airway responsiveness produced by a vibrating mesh nebulizer versus a jet nebulizer

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Nolin JD, Lai Y, Ogden HL, Manicone AM, Murphy RC, An D, Frevert CW, Ghomashchi F, Naika GS, Gelb MH, Gauvreau GM, Piliponsky AM, Altemeier WA, Hallstrand TS. 2017

Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen

JCI Insight

Capaldi DPI, Sheikh K, Eddy RL, Guo F, Svenningsen S, Nair P, McCormack DG, Parraga G 2017

Free-breathing Functional Pulmonary MRI: Response to Bronchodilator and Bronchoprovocation in Severe Asthma

Academic Radiology

Nair P, Wenzel S, Rabe KF, Bourdin A, Lugogo NL, Kuna P, Barker P, Sproule S, Ponnarambil S, Goldman M 2017

Oral Glucocorticoid-Sparing effect of Benralizumab in Severe asthma

New England Journal of Medicine

Nair P, Barker P, Goldman M. 2017

Glucocorticoid Sparing of Benralizumab in Asthma

The New England Journal of Medicine

Oliveria JP, Salter BM, Phan S, Obminski CD, Munoz CE, Smith SG, Scime TX, Watson RM, Sehmi R, Gauvreau GM. 2017

Allergic asthmatics with allergy have elevated levels of IgE+ B cells in the airways

Journal of Allergy and Clinical Immunology

Oliveria JP, Salter BM, MacLean J, Kotwal S, Smith A, Harris JM, Scheerens H, Sehmi R, Gauvreau GM 2017

Increased IgE+ B cells in sputum, but not blood, bone marrow or tonsils after inhaled allergen challenge in asthmatic subjects

American Journal of Respiratory and Critical Care Medicine

Sadatsafavi M, Chen W, Tavakoli H, Rolf JD, Rousseau R, FitzGerald JM 2016

Economic Burden of Asthma Study Group. Saving in medical costs by achieving guideline-based asthma symptom control: a population-based study

Allergy

Cockcroft DW 2016

Giants in allergy-immunology. Frederick E. “Freddy” Hargreave, MB ChB, MD

Annals of Allergy, Asthma & Immunology

Silkoff PE, Laviolette M, Singh D, FitzGerald JM, Kelsen S, Backer V, Porsbjerg C, Girodet PO, Berger P, Kline JN, Khatri S, Chanez P, Susulic VS, Barnathan ES, Baribaud F, Loza MJ; ADEPT Investigators. 2016

Longitudinal stability of asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study

Respiratory Research

Ehteshami-Afshar S, FitzGerald JM, Carlsten C, Tavakoli H, Rousseau R, Tan WC, Rolf JD, Sadatsafavi M. 2016

The impact of comorbidities on productivity loss in asthma patients

Respiratory Research

Wong A, Tavakoli H, Sadatsafavi M, Carlsten C, FitzGerald JM. 2016

Asthma control and productivity loss in those with work-related asthma: a population-based study. 5:0.

Journal of Asthma

Blais CM, Davis BE, Cockcroft DW. 2016

Duration of bronchoprotection of the long-acting muscarinic antagonists tiotropium & glycopyrronium against methacholine-induced bronchoconstriction in mild asthmatics

Respiratory Medicine

Wang H, Chen R, Xie J, Zhang Q, Deng Y, Zeng Q, Zhu Z, Ding M, Lai Z, Kolb M, O'Byrne P, Chen R, Zhong N. 2016

A 43-year-old man with cough, expectoration and recurrent wheezing

Journal of Thoracic Disease

Poureslami I, Shum J, Nimmon L, FitzGerald JM. 2016

Culturally Specific Evaluation of Inhaler Techniques in Asthma

Respiratory Care

Kerstjens HAM, O'Byrne PM 2016

Tiotropium for the treatment of asthma: a drug safety evaluation

Expert Opinion on Drug Safety

Mitchell PD, O'Byrne PM 2016

Surfactant protein-D and asthma

CHEST

Nair P, O'Byrne PM 2016

Measuring Eosinophils to Make Treatment Decisions in Asthma

CHEST

FitzGerald JM, Bleecker ER, Nair P, Korn S, Ohta K, Lommatzsch M, Ferguson GT, Busse WW, Barker P, Sproule S, Gilmartin G, Werkstrom V, Aurivillius M, Goldman M; CALIMA study investigators 2016

Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial

The Lancet

O'Byrne PM, Metev H, Puu M, Richter K, Keen C, Uddin M, Larsson B, Cullberg M, Nair P. 2016

Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised trial

The Lancet Respiratory Medicine

O'Byrne PM, Jacques L, Goldfrad C, Kwon N-H, Perrio M, Yates LJ, Busse WW. 2016

Integrated safety and efficacy analysis of once-daily fluticasone furoate for the treatment of asthma

Respiratory Research

FitzGerald JM, Sadatsafavi M. 2016

Less chaos in the prognosis of asthma-chronic obstructive lung disease overlap

The Lancet Respiratory Medicine

Bleecker ER, FitzGerald JM, Chanez P, Papi A, Weinstein SF, Barker P, Sproule S, Gilmartin G, Aurivillius M, Werkström V, Goldman M; SIROCCO study investigators. 2016

Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial

The Lancet

Zuccaro L, Cox A, Pray C, Radford K, Novakowski K, Dorrington M, Surette M, Bowdish D, Nair P 2016

Histone deacetylase activity and recurrent neutrophilic bronchitis in severe eosinophilic asthma

Allergy

Gauvreau GM, Boulet LP, Leigh R, Cockcroft DW, Davis BE, Mayers I et al. 2016

Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting the allergen-induced early asthmatic response

Journal of Allergy and Clinical Immunology

Aleman F, Lim HF, Nair P 2016

Eosinophilic Endotype of Asthma

Immunology and Allergy Clinics of North America

Mukherjee M, Nair P 2016

Blood or sputum eosinophils to guide asthma therapy?

The Lancet Respiratory Medicine

Mitchell PD, Salter BM, Oliveria JP, El-Gammal A, Tworek D, Smith SG, Sehmi R, Gauvreau GM, Butler M, O'Byrne PM 2016

Glucagon Like Peptide-1 receptor expression on human eosinophils and its regulation of eosinophil activation

Clinical and Experimental Allergy

Tang W, Smith SG, Salter B, Oliveria JP, Mitchell P, Nusca GM, Howie K, Gauvreau GM, O'Byrne PM, Sehmi R 2016

Allergen-Induced Increases in Interleukin-25 and Interleukin-25 Receptor Expression in Mature Eosinophils from Atopic Asthmatics

International Archives of Allergy and Immunology

Todd CM, Salter BM, Murphy DM, Watson RM, Howie KJ, Milot J, Sadeh J, Boulet LP, O'Byrne PM, Gauvreau GM 2016

The effects of a CXCR1/CXCR2 antagonist on neutrophil migration in mild atopic asthmatic subjects

Pulmonary Pharmacology and Therapeutics

Salter BM, Manzoor F, Beaudin S, Kjarsgaard M, Nair P, Gauvreau GM, Sehmi R 2016

Dysregulation of Vascular Endothelial Progenitor Cells Lung-Homing in Subjects with COPD

Canadian Respiratory Journal

Gauvreau GM, Boulet LP, FitzGerald JM, Cockcroft DW, Davis BE, Leigh R, Tanaka M, Fourre JA, Tanaka M, Nabata T, O'Byrne PM 2016

A dual CysLT1/2 antagonist attenuates allergen-induced airway responses in subjects with mild allergic asthma

Allergy

El-Gammal A, Oliveria JP, Howie K, Watson R, Mitchell P, Chen R, Baatjes A, Smith S, Al-Sajee D, Hawke TJ, Killian KJ, Gauvreau GM, O'Byrne PM 2016

Allergen-induced Changes in Bone Marrow and Airway Dendritic Cells in Subjects with Asthma

American Journal of Respiratory and Critical Care Medicine

Salter BM, Oliveria JP, Nusca G, Smith SG, Tworek D, Mitchell PD, Watson RM, Sehmi R, Gauvreau GM 2016

IL-25 and IL-33 induce Type 2 inflammation in basophils from subjects with allergic asthma

Respiratory Research

Tworek D, Smith SG, Salter BM, Baatjes AJ, Scime T, Watson R, Obminski C, Gauvreau GM, O'Byrne PM 2016

IL-25 Receptor Expression on Airway Dendritic Cells after Allergen Challenge in Subjects with Asthma

American Journal of Respiratory and Critical Care Medicine

Salter BM, Nusca G, Tworek D, Oliveria JP, Smith SG, Watson RM, Scime T, Obminski C, Sehmi R, Gauvreau GM 2016

Expression of activation markers in circulating basophils and the relationship to allergen-induced bronchoconstriction in subjects with mild allergic asthma

Journal of Allergy and Clinical Immunology

Cockcroft DW 2015

Methacholine challenge. PD20 versus PC20

Annals of the American Thoracic Society

Bousquet J, et al. 2015

MACVIA-ARIA Sentinel Network for allergic rhinitis (MASK-rhinitis): The new generation guideline implementation

Allergy

Cos C, Kjarsgaard M, Cox G, Surette MC, Nair P. 2015

A multi-dimensional approach to the management of severe asthma: inflammomentry, molecular microbiology and bronchial thermoplasty

Canadian Respiratory Journal

Wang H, Dasgupta A, Lee KA, Cook RJ, Nair P. 2015

Changing patterns of Sputum Cell Counts During Successive Exacerbations of Chronic Obstructive Pulmonary Disease

COPD

Smith SG, Chen R, Kjarsgaard M, Huang C, Oliveria JP, O'Byrne P, Gauvreau G, Boulet L-P, Lemiere C, Martin JG, Nair P, Sehmi R. 2015

Increased Numbers of Activated Group 2 Innate Lymphoid Cells in the Airways of Severe Asthmatics with Persistent Airway Eosinophilia

Journal of Allergy & Clinical Immunology

Nishioka M, Venkatesan N, Dessalle K, Mogas A, Kyoh S, Lin TY, Nair P, Baglole CJ, Eidelman DH, Ludwig MS, Hamid Q. 2015

Fibroblast-epithelial cell interactions drive epithelial-mesenchymal transition differently in cells from normal and COPD patients

Respiratory Research

Sheridan JA, Zago M, Nair P, Li PZ, Bourbeau J, Tan WC, Hamid Q, Eidelman DH, Benedetti AL, Baglole CJ. 2015

Decreased expression of the NF-kB family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression

Respiratory Research

Mitchell PD, El-Gammal AI, O'Byrne PM 2015

Emerging monoclonal antibodies as targeted innovative therapeutic approaches to asthma

Clinical Pharmacology and Therapeutics

Chu DK, Al-Garawi A, Llop-Guevara A, Pillai RA, Radford K, Shen P, Walker TD, Goncharova S, Calhou WJ, Nair P, Jordana M. 2015

Therapeutic potential of anti-IL-6 therapies for granulocytic airway inflammation in asthma

Allergy, Asthma & Clinical Immunology

Ellis A, Soliman M, Steacy L, Boulay M, Boulet L, Keith P, Vliagoftis H, Waserman S, Neighbour H 2015

The Allergic Rhinitis – Clinical Investigator Collaborative (AR-CIC): nasal allergen challenge protocol optimization for studying AR pathophysiology and evaluating novel therapies

Allergy, Asthma & Clinical Immunology

Boulet LP, Gauvreau GM, Cockcroft DW, Davis B, Vachon L, Cormier Y, O'Byrne PM 2015

Effects of ASM-024, a modulator of acetylcholine receptor function, on airway responsiveness and allergen-induced responses in patients with mild asthma

Canadian Respiratory Journal

Boulet LP, Gauvreau G, Boulay ME, O'Byrne P, Cockcroft DW 2015

Allergen-induced early and late asthmatic responses to inhaled seasonal and perennial allergens

Clinical & Experimental Allergy

Boulet L-P, O'Byrne PM. 2015

Asthma and Exercise-Induced Bronchoconstriction in Athletes

The New England Journal of Medicine

Cockcroft DW, Davis BE, Roh Y, Lourens JA 2015

Effect of ingested H1 antihistamines on methacholine challenge

Journal of Allergy and Clinical Immunology

Gauvreau GM, Boulet LP, Leigh R, Cockcroft DW, Killian KJ, Davis BE, Deschesnes F, Watson RM, Swystun V, Mårdh CK, Wessman P, Jorup C, Aurivillius M, O'Byrne PM 2015

A nonsteroidal glucocorticoid receptor agonist inhibits allergen-induced late asthmatic responses

American Journal of Respiratory and Critical Care Medicine

Kwofie K, Scott M, Rodrigues R, Guerette 2015J, Radford K, Nair P, Richards CD 2015

Regulation of IL-17A responses in human airway smooth muscle cells by Onostatin M

Respiratory Research

Li JJ, Tay HL, Maltby S, Xiang Y, Eyers F, Hatchwell L, Zhou H,  Toop HD, Morris JC,Nair P, Mattes J, Foster PS, Yang M 2015

MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity

Journal of Allergy and Clinical Immunology

Brannan JD, Bood J, Alkhabaz A, Balgoma D, Otis J, Delin I,Dahlén B, Wheelock CE, Nair P, Dahlén SE, O'Byrne PM 2015

The effect of omega-3 fatty acids on bronchial hyperresponsiveness, sputum eosinophilia and mast cell mediators in asthma

Chest

Nair P, Aziz-ur-Rehman A, Radford K 2015

Therapeutic implications of neutrophilic asthma

Current Opinion in Pulmonary Medicine

Olfert J, Gjevre J,Cockcroft D. 2015

A nonallergic mechanism for nut-induced wheeze

Journal of Allergy and Clinical Immunology: In Practice

Davis BE, Amakye DO, Cockcroft DW 2015

Airway responsiveness to mannitol 24 hours after 7b allergen challenge in atopic asthmatics

Allergy

Lim HF, Nair P 2015

Efficacy and safety of reslizumab in patients with moderate to severe eosinophilic asthma

Expert Review of Respiratory Medicine

Janssen LJ, Gauvreau GM, Killian KJ, O'Byrne PM 2015

The Effects of Repeated Bronchoprovocation on FEV1 in Subjects with Asthma

Annals of the American Thoracic Society

Baatjes AJ, Smith SG, Dua B, Watson R, Gauvreau GM, O'Byrne PM 2015

Treatment with anti-OX40L or anti-TSLP does not alter the frequency of T regulatory cells in allergic asthmatics

Allergy

Salter BM, Oliveria JP, Nusca G, Smith SG, Watson RM, Comeau M, Sehmi R, Gauvreau GM 2015

Thymic stromal lymphopoietin activation of basophils in patients with allergic asthma is IL-3 dependent

Journal of Allergy and Clinical Immunology

El-Gammal AI, Killian KJ, Scime TX, Beaudin S, Schlatman A, Cockcroft DW, Gauvreau GM 2015

Comparison of the provocative concentration of methacholine causing a 20% fall in FEV1 between the AeroEclipse II breath-actuated nebulizer and the wright nebulizer in adult subjects with asthma

Annals of the American Thoracic Society

Watson BM, Oliveria JP, Nusca GM, Smith SG, Beaudin S, Dua B, Watson RM, Assayag EI, Cormier YF, Sehmi R, Gauvreau GM 2015

Inhibition of allergen-induced basophil activation by ASM-024, a nicotinic receptor ligand

International Archives of Allergy and Immunology

Smith SG, Gugilla A, Mukherjee M, Merim K, Irshad A, Tang W, Kinoshita T, Watson B, Oliveria JP, Comeau M, O'Byrne PM, Gauvreau GM, Sehmi R 2015

Thymic stromal lymphopoietin and IL-33 modulate migration of hematopoietic progenitor cells in patients with allergic asthma

Journal of Allergy and Clinical Immunology

Mukherjee M, Sehmi R, Nair P. 2014

Anti-IL5 therapy for asthma and beyond

World Allergy Organization Journal

Nair P, Zhang Q, Brennan J. 2014

A perspective on point of care tests for eosinophilic bronchitis

Journal of Asthma

Gauvreau GM, Harris JM, Boulet LP, Sheerens H, FitzGerald JM, Putnam WS, Cockcroft DW, Davis BE, Leigh R, Zheng Y, Dahlén B, Wang Y, Maciuca R, Mayers I, Liao XC, Wu LC, Matthews JG, O'Byrne PM. 2014

Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production

Science Translational Medicine

Gauvreau GM, O'Byrne PM, Boulet L-P, Wang Y, Cockcroft DW, Bigler J, FitzGerald JM, Boedigheimer M, Davis BE, Dias C, Gorski KS, Smith L, Bautista E, Comeau MR, Leigh R, Parnes JR. 2014

Effects of an Anti-TSLP Antibody on Allergen-Induced Asthmatic Responses

The New England Journal of Medicine

Gauvreau G. M. , Boulet L.-P. , Cockcroft D. W. , J. M. FitzGerald, I. Mayers, C. Carlsten, M. Laviolette, K. J. Killian, B. E. Davis, M. Larché, C. Kipling, B. Dua, S. Mosesova, Putnam W. , Zheng Y. , Scheerens H., McClintock D. , Matthews J. G. and O& 2014

OX40L blockade on allergen-induced airway responses in subjects with mild asthma

Clinical Experimental Allergy

Normansell R, Walker S, Milan SJ, Walters EH, Nair P. 2014

Omalizumab for asthma in adults and children

Cochrane Databsae Systematic Reviews

Jones NL, O'Byrne P. 2014

Respiratory Medicine at McMaster University, Hamilton, Ontario: 1698 to 2013

Canadian Respiratory Journal

Dahlén, S-E 2014

TSLP in Asthma – A New Kid on the Block?

The New England Journal of Medicine

Nair P. 2014

Anti-IL5 monoclonal antibody to treat severe eosinophilic asthma

The New England Journal of Medicine

Nair P, Denis S, Cancelliere L, Radford K. Efthimiadis A, Rosano M, Hanrahan J 2014

The effects of an epithelial barrier protective cationic aerosol on allergen-induced airway inflammation in asthma: a randomized, placebo-controlled clinical trial

Clinical & Experimental Allergy

Cockcroft DW. 2014

Allergen-induced asthma

Canadian Respiratory Journal

Jin H, Hallstrand TS, Daly SD, Matzke MM,Nair P, Bigelow DJ, Pounds JG, Zangar RC. 2014

A halotyrosine antibody that detects increased protein modifications in asthma patients

Journal of Immunological Methods

Chang Y, Al-Alwan L, Alshakfa S, Audusseau S, Mogas AK , Chouiali F, Nair P, Baglole CJ, Hamid Q, Eidelman DH 2014

Upregulation of IL-17A/F from human lung tissue explants with cigarette smoke exposure: implications for COPD

Respiratory Research

Morissette MC, Jobse BN, Nikota JK, Shen P, Labiris RN, Kolbeck R, Nair P,Humbles AA, Stampfli MR, Thayaparan D, Nikota JK 2014

Persistence of pulmonary tertiary lymphoid tissues and anti-nuclear antibodies following cessation of cigarette smoke exposure

Respiratory Research

Neighbour H,Goodwin J, Strychowsky J, Rahman S, Abdelshaheed R,Nair P, Sommer DD 2014

Relationship between sputum eosinophilia and sinus disease in patients with eosinophilic bronchitis

American Journal of Rhinology & Allergy

Verschoor CP, Dorrington MG, Novakowski KE, Kaiser J, Radford K,Nair P, Anipindi V, Kaushic C, Surette MG, Bowdish DME 2014

MicroRNA-155 is required for the clearance of Streptococcus pneumoniae from the nasopharynx

Infection and Immunity

Hambly N, Nair P 2014

Monoclonal antibodies for the treatment of refractory asthma

Current Opinion in Pulmonary Medicine

Nataraj RTY,Cockcroft DW, Fladeland DA. 2014

An uncommon cause of wheeze

Journal of Allergy and Clinical Immunology: In Practice

Davis BE, Stewart SL, Martin AL, Cockcroft DW. 2014

Low levels of fractional exhaled nitric oxide and deep inhalation bronchoprotection are associated with mannitol non-responsiveness in asthma

Respiratory Medicine

Lim HF, Nair P. 2013

The evolution of sputum cytrometry to assess bronchitis

Canadian Respiratory Journal

Singh A, Yamamoto M, Kam SHY, Ruan J, Gauvreau GM, O'Byrne PM, FitzGerald JM, Schellenberg R, Boulet L-P, Wojewodka G, Kanagaratham C, De Sanctis J, Radzioch D, Tebbutt SJ. 2013

Gene-metabolite expression in blood can discriminate allergen-induced isolated early from dual asthmatic responses

PLOS ONE

Davidson WJ, Wong LE, The S, Leigh R. 2013

The impact of diurnal variation on induced sputum cell counts in healthy adults

Clinical and Translational Allergy

Kam SHY, Singh A, He J-Q, Ruan J, Gauvreau GM, O'Byrne PM, FitzGerald JM, Tebbutt SJ. 2012

Peripheral blood gene expression changes during allergen inhalation challenge in atopic asthmatic individuals

Journal of Asthma

Singh A, Cohen Freue GV, Oosthuizen JL, Kam SHY, Ruan J, Takhar M, Gauvreau GM, O'Byrne PM, FitzGerald JM, Boulet L-P, Borchers CH, Tebbutt SJ. 2012

Plasma proteomics can discriminate isolated early from dual responses in asthmatic individuals undergoing an allergen inhalation challenge

Proteomics ? Clinical Applications

Yamamoto M, Singh A, Ruan J, Gauvreau GM, O'Byrne PM, Carlsten C, FitzGerald JM, Boulet L-P, Tebbutt SJ. 2012

Decreased miR-192 expression in peripheral blood of asthmatic individuals undergoing an allergen inhalation challenge

BMC Genomics

Davis BE, Cockcroft DW. 2012

Past, present and future uses of methacholine challenge

Expert Review in Respiratory Medicine

Boulet L-P. 2012

Cough and upper airway disorders in elite athletes: a critical review

British Journal of Sports Medicine

Lougheed MD, Lemière C, Ducharme FM, Lickai C, Dell SD, Rowe BH, Fitzgerald M, Leigh R, Watson W, Boulet L-P. 2012

Canadian Thoracic Society 2012 Guideline Update: Diagnosis and Management of Asthma in Preschoolers, Children and Adults: Executive Summary

Canadian Respiratory Journal

Davenport MH, Beaudin AE, Brown AD, Leigh R, Poulin MJ. 2012

Ventilatory responses to exercise and CO2 after menopause in healthy women: effects of age and fitness

Respiratory Physiology & Neurobiology

Fitzgerald M. 2012

Randomised controlled trial: In two parallel pragmatic equivalence trials, leukotriene receptor antagonists as initial therapy for asthma compared with inhaled corticosteroids and as add on therapy to ICS compared with adding long-acting β agonists provide

Evidence-Based Medicine for Primary Care and Internal Medicine

Gauvreau GM, Boulet LP, Cockcroft DW, Fitzgerald JM, Carlsten C, Davis BE, Deschesnes F, Duong M, Durn BL, Howie KJ, Hui L, Kasaian MT, Killian KJ, Strinich TX, Watson RM, Y N, Zhou S, Raible D, O'Byrne PM. 2011

The effects of IL-13 blockade on allergen-induced airway responses in mild atopic asthma

American Journal of Respiratory and Critical Care Medicine

Rousseau M-C, Boulay M-E, Goronfolah L, Denburg J, Keith P, Boulet L-P. 2011

Comparative responses to nasal allergen challenge in allergic rhinitic subjects with or without asthma

Allergy, Asthma & Clinical Immunology

Peters GE, Davis BE, Cockcroft DW. 2011

Characterization of the methacholine PC15

Annals of Allergy, Asthma & Immunology

Kelly MM, King EM, Rider CF, Gwozd C, Holden NS, Eddleston J, Zuraw B, Leigh R, O'Byrne PM, Newton R. 2011

Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide

British Journal of Pharmacology

Li X, Yang A, Huang H, Zhang X, Town J, Davis B, Cockcroft DW, Gordon JR. 2010

Induction of type 2 T helper cell allergen tolerance by IL-10-differentiated regulatory dendritic cells

American Journal of Respiratory Cell and Molecular Biology

Kelly MM, O'Connor TM, Leigh R, Otis J, Gwozd C, Gauvreau GM, Gauldie J, O'Byrne PM. 2010

Effects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthma

Journal of Allergy and Clinical Immunology

Gaurvreau GM, Boulet LP, Cockcroft DW, FitzGerald JM, Carlsten C, Davis BE, Deschesnes F, Duong M, Durn BL, Howie KJ, Hui L, Kasaian MT, Killian KJ, Strinich TX, Watson RM, Zhou S, Raible D, O'Byrne PM. 2010

Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma

American Journal of Respiratory and Critical Care Medicine

O’Byrne PM, Gauvreau GM, Brannan JD 2009

Provoked models of asthma: What have we learnt?

Clinical & Experimental Allergy

Al-Garawi A, Fattouh R, Walker T, Jamula E, Botelho F, Goncharova S, Reed J, Stampfli M, O'Byrne P, Coyle A, Jordana M. 2009

Acute, but not resolved, influenza A infection enhances susceptibility to house dust mite-induced allergic disease

The Journal of Immunology

Davis BE, Illamperuma C, Gauvreau GM, Watson RM, O'Byrne PM, Deschesnes F, Boulet LP, Cockcroft DW. 2009

Single dose desloratadine and montelukast and allergen-induced late airway responses

European Respiratory Journal

Boulet L-P, Lemière C, Gauvreau GM, Olivenstein R, Lougheed D, Paradis B, O’Byrne P, Pageau R, Renzi PM. 2009

Safety, pharmacodynamics and pharmacokinetics of TPI 1020 in smokers with asthma

Respiratory Medicine

O'Byrne PM, Gauvreau G. 2009

Phosphodiesterase-4 inhibition in COPD

The Lancet

O'Byrne PM, Gauvreau GM, Murphy DM 2009

Efficacy of leukotriene receptor antagonists and synthesis inhibitors in asthma

Journal of Allergy and Clinical Immunology

O'Byrne PM, van der Linde J, Cockcroft DW, Gauvreau GM, Brannan JD, FitzGerald JM, Watson RM, Milot J, Davis B, O?Connor M, Hart L, Korducki L, Hamilton J. 2009

Prolonged bronchoprotection against
inhaled methacholine by inhaled BI 1744, a long-acting β2-agonist, in mild asthmatics

Journal of Allergy and Clinical Immunology

Gauvreau GM, Boulet L-P, Cockcroft DW, Baatjes A, Cote J, Deschesnes F, Davis B, Strinich T, Howie K, Duong M, Watson RM, Renzi PM, O?Byrne, PM. 2008

Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses in mild allergic asthmatics

American Journal of Respiratory and Critical Care Medicine

Duong M, Cockcroft D, Boulet L-P, Ahmed T, Iverson H, Atkinson D, Stahl E, Watson R, Davis B, Milo J, Gauvreau G, O?Byrne P. 2008

The effect of IVX-0142, a heparin-derived hypersulfated disaccharide, on the allergic airway responses in asthma

Allergy

Bousquet J et al, including Denburg J, Boulet L-P, Lemiere C 2008

Allergic rhinitis and its impact on asthma (ARIA) 2008 (in collaboration with the World Health Organization, GA2LEN and AllerGen)

Allergy

Boulet LP , Prince P , Turcotte H , Lemière C, Olivenstein R, Laprise C, Larivee P , Bégin P, Laviolette M. 2006

Clinical features and airway inflammation in mild asthma versus asymptomatic airway hyperresponsiveness

Respiratory Medicine

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