CIC Publications

Refereed Journal Articles

The database below lists the refereed journal articles that have emerged from the Canadian Investigators Collaborative (CIC) Legacy Project.

The database can be sorted and/or searched by different data fields. When searching by author, use last name only.

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Boulet LP , Prince P , Turcotte H , Lemière C, Olivenstein R, Laprise C, Larivee P , Bégin P, Laviolette M. 2006

Clinical features and airway inflammation in mild asthma versus asymptomatic airway hyperresponsiveness

Respiratory Medicine

Gauvreau GM, Boulet L-P, Cockcroft DW, Baatjes A, Cote J, Deschesnes F, Davis B, Strinich T, Howie K, Duong M, Watson RM, Renzi PM, O?Byrne, PM. 2008

Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses in mild allergic asthmatics

American Journal of Respiratory and Critical Care Medicine

175 952-958
Duong M, Cockcroft D, Boulet L-P, Ahmed T, Iverson H, Atkinson D, Stahl E, Watson R, Davis B, Milo J, Gauvreau G, O?Byrne P. 2008

The effect of IVX-0142, a heparin-derived hypersulfated disaccharide, on the allergic airway responses in asthma


63 1195-1201
Bousquet J et al, including Denburg J, Boulet L-P, Lemiere C 2008

Allergic rhinitis and its impact on asthma (ARIA) 2008 (in collaboration with the World Health Organization, GA2LEN and AllerGen)


O’Byrne PM, Gauvreau GM, Brannan JD 2009

Provoked models of asthma: What have we learnt?

Clinical & Experimental Allergy

39(2) 181-192
Al-Garawi A, Fattouh R, Walker T, Jamula E, Botelho F, Goncharova S, Reed J, Stampfli M, O'Byrne P, Coyle A, Jordana M. 2009

Acute, but not resolved, influenza A infection enhances susceptibility to house dust mite-induced allergic disease

The Journal of Immunology

182 3095-3104
Davis BE, Illamperuma C, Gauvreau GM, Watson RM, O'Byrne PM, Deschesnes F, Boulet LP, Cockcroft DW. 2009

Single dose desloratadine and montelukast and allergen-induced late airway responses

European Respiratory Journal

33 1302-1308
Boulet L-P, Lemière C, Gauvreau GM, Olivenstein R, Lougheed D, Paradis B, O’Byrne P, Pageau R, Renzi PM. 2009

Safety, pharmacodynamics and pharmacokinetics of TPI 1020 in smokers with asthma

Respiratory Medicine

103 <a href=
O'Byrne PM, Gauvreau G. 2009

Phosphodiesterase-4 inhibition in COPD

The Lancet

374 665-667
O'Byrne PM, Gauvreau GM, Murphy DM 2009

Efficacy of leukotriene receptor antagonists and synthesis inhibitors in asthma

Journal of Allergy and Clinical Immunology

124 397-403
O'Byrne PM, van der Linde J, Cockcroft DW, Gauvreau GM, Brannan JD, FitzGerald JM, Watson RM, Milot J, Davis B, O?Connor M, Hart L, Korducki L, Hamilton J. 2009

Prolonged bronchoprotection against
inhaled methacholine by inhaled BI 1744, a long-acting β2-agonist, in mild asthmatics

Journal of Allergy and Clinical Immunology

124 1217-1224
Li X, Yang A, Huang H, Zhang X, Town J, Davis B, Cockcroft DW, Gordon JR. 2010

Induction of type 2 T helper cell allergen tolerance by IL-10-differentiated regulatory dendritic cells

American Journal of Respiratory Cell and Molecular Biology

42 190-199
Kelly MM, O'Connor TM, Leigh R, Otis J, Gwozd C, Gauvreau GM, Gauldie J, O'Byrne PM. 2010

Effects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthma

Journal of Allergy and Clinical Immunology

125 349-356
Gaurvreau GM, Boulet LP, Cockcroft DW, FitzGerald JM, Carlsten C, Davis BE, Deschesnes F, Duong M, Durn BL, Howie KJ, Hui L, Kasaian MT, Killian KJ, Strinich TX, Watson RM, Zhou S, Raible D, O'Byrne PM. 2010

Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma

American Journal of Respiratory and Critical Care Medicine

183 (3) 1007-14
Gauvreau GM, Boulet LP, Cockcroft DW, Fitzgerald JM, Carlsten C, Davis BE, Deschesnes F, Duong M, Durn BL, Howie KJ, Hui L, Kasaian MT, Killian KJ, Strinich TX, Watson RM, Y N, Zhou S, Raible D, O'Byrne PM. 2011

The effects of IL-13 blockade on allergen-induced airway responses in mild atopic asthma

American Journal of Respiratory and Critical Care Medicine

183 (8) 1007-14
Rousseau M-C, Boulay M-E, Goronfolah L, Denburg J, Keith P, Boulet L-P. 2011

Comparative responses to nasal allergen challenge in allergic rhinitic subjects with or without asthma

Allergy, Asthma & Clinical Immunology

7 8
Peters GE, Davis BE, Cockcroft DW. 2011

Characterization of the methacholine PC15

Annals of Allergy, Asthma & Immunology

107 (4) 371
Kelly MM, King EM, Rider CF, Gwozd C, Holden NS, Eddleston J, Zuraw B, Leigh R, O'Byrne PM, Newton R. 2011

Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide

British Journal of Pharmacology

165 1737-47
Kam SHY, Singh A, He J-Q, Ruan J, Gauvreau GM, O'Byrne PM, FitzGerald JM, Tebbutt SJ. 2012

Peripheral blood gene expression changes during allergen inhalation challenge in atopic asthmatic individuals

Journal of Asthma

1-8 (2012)
Singh A, Cohen Freue GV, Oosthuizen JL, Kam SHY, Ruan J, Takhar M, Gauvreau GM, O'Byrne PM, FitzGerald JM, Boulet L-P, Borchers CH, Tebbutt SJ. 2012

Plasma proteomics can discriminate isolated early from dual responses in asthmatic individuals undergoing an allergen inhalation challenge

Proteomics ? Clinical Applications

6(9-10) 476-485
Yamamoto M, Singh A, Ruan J, Gauvreau GM, O'Byrne PM, Carlsten C, FitzGerald JM, Boulet L-P, Tebbutt SJ. 2012

Decreased miR-192 expression in peripheral blood of asthmatic individuals undergoing an allergen inhalation challenge

BMC Genomics

13(1) 655
Davis BE, Cockcroft DW. 2012

Past, present and future uses of methacholine challenge

Expert Review in Respiratory Medicine

6 (3) 321-329
Boulet L-P. 2012

Cough and upper airway disorders in elite athletes: a critical review

British Journal of Sports Medicine

46 417-421
Lougheed MD, Lemière C, Ducharme FM, Lickai C, Dell SD, Rowe BH, Fitzgerald M, Leigh R, Watson W, Boulet L-P. 2012

Canadian Thoracic Society 2012 Guideline Update: Diagnosis and Management of Asthma in Preschoolers, Children and Adults: Executive Summary

Canadian Respiratory Journal

Davenport MH, Beaudin AE, Brown AD, Leigh R, Poulin MJ. 2012

Ventilatory responses to exercise and CO2 after menopause in healthy women: effects of age and fitness

Respiratory Physiology & Neurobiology

184(2012) 1-8
Fitzgerald M. 2012

Randomised controlled trial: In two parallel pragmatic equivalence trials, leukotriene receptor antagonists as initial therapy for asthma compared with inhaled corticosteroids and as add on therapy to ICS compared with adding long-acting β agonists provide

Evidence-Based Medicine for Primary Care and Internal Medicine

17 44-45
Lim HF, Nair P. 2013

The evolution of sputum cytrometry to assess bronchitis

Canadian Respiratory Journal

20(6) 415-16
Singh A, Yamamoto M, Kam SHY, Ruan J, Gauvreau GM, O'Byrne PM, FitzGerald JM, Schellenberg R, Boulet L-P, Wojewodka G, Kanagaratham C, De Sanctis J, Radzioch D, Tebbutt SJ. 2013

Gene-metabolite expression in blood can discriminate allergen-induced isolated early from dual asthmatic responses


8 e67907
Davidson WJ, Wong LE, The S, Leigh R. 2013

The impact of diurnal variation on induced sputum cell counts in healthy adults

Clinical and Translational Allergy

3(1) 8
Mukherjee M, Sehmi R, Nair P. 2014

Anti-IL5 therapy for asthma and beyond

World Allergy Organization Journal

7(1) 32
Nair P, Zhang Q, Brennan J. 2014

A perspective on point of care tests for eosinophilic bronchitis

Journal of Asthma

52(3) 254-61
Gauvreau GM, Harris JM, Boulet LP, Sheerens H, FitzGerald JM, Putnam WS, Cockcroft DW, Davis BE, Leigh R, Zheng Y, Dahlén B, Wang Y, Maciuca R, Mayers I, Liao XC, Wu LC, Matthews JG, O'Byrne PM. 2014

Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production

Science Translational Medicine

6 243ra85
Gauvreau GM, O'Byrne PM, Boulet L-P, Wang Y, Cockcroft DW, Bigler J, FitzGerald JM, Boedigheimer M, Davis BE, Dias C, Gorski KS, Smith L, Bautista E, Comeau MR, Leigh R, Parnes JR. 2014

Effects of an Anti-TSLP Antibody on Allergen-Induced Asthmatic Responses

The New England Journal of Medicine

370(22) 2102-2010
Gauvreau G. M. , Boulet L.-P. , Cockcroft D. W. , J. M. FitzGerald, I. Mayers, C. Carlsten, M. Laviolette, K. J. Killian, B. E. Davis, M. Larché, C. Kipling, B. Dua, S. Mosesova, Putnam W. , Zheng Y. , Scheerens H., McClintock D. , Matthews J. G. and O& 2014

OX40L blockade on allergen-induced airway responses in subjects with mild asthma

Clinical Experimental Allergy

44(1) 29-37
Normansell R, Walker S, Milan SJ, Walters EH, Nair P. 2014

Omalizumab for asthma in adults and children

Cochrane Databsae Systematic Reviews

Jones NL, O'Byrne P. 2014

Respiratory Medicine at McMaster University, Hamilton, Ontario: 1698 to 2013

Canadian Respiratory Journal

Dahlén, S-E 2014

TSLP in Asthma – A New Kid on the Block?

The New England Journal of Medicine

370 2144-2145
Nair P. 2014

Anti-IL5 monoclonal antibody to treat severe eosinophilic asthma

The New England Journal of Medicine

371 1249-1251
Nair P, Denis S, Cancelliere L, Radford K. Efthimiadis A, Rosano M, Hanrahan J 2014

The effects of an epithelial barrier protective cationic aerosol on allergen-induced airway inflammation in asthma: a randomized, placebo-controlled clinical trial

Clinical & Experimental Allergy

44(9) 1200-3
Cockcroft DW. 2014

Allergen-induced asthma

Canadian Respiratory Journal

21(5) 279-282
Jin H, Hallstrand TS, Daly SD, Matzke MM,Nair P, Bigelow DJ, Pounds JG, Zangar RC. 2014

A halotyrosine antibody that detects increased protein modifications in asthma patients

Journal of Immunological Methods

403(1-2) 17-25
Chang Y, Al-Alwan L, Alshakfa S, Audusseau S, Mogas AK , Chouiali F, Nair P, Baglole CJ, Hamid Q, Eidelman DH 2014

Upregulation of IL-17A/F from human lung tissue explants with cigarette smoke exposure: implications for COPD

Respiratory Research

15 145
Morissette MC, Jobse BN, Nikota JK, Shen P, Labiris RN, Kolbeck R, Nair P,Humbles AA, Stampfli MR, Thayaparan D, Nikota JK 2014

Persistence of pulmonary tertiary lymphoid tissues and anti-nuclear antibodies following cessation of cigarette smoke exposure

Respiratory Research

15 49
Neighbour H,Goodwin J, Strychowsky J, Rahman S, Abdelshaheed R,Nair P, Sommer DD 2014

Relationship between sputum eosinophilia and sinus disease in patients with eosinophilic bronchitis

American Journal of Rhinology & Allergy

28(5) 378-382
Verschoor CP, Dorrington MG, Novakowski KE, Kaiser J, Radford K,Nair P, Anipindi V, Kaushic C, Surette MG, Bowdish DME 2014

MicroRNA-155 is required for the clearance of Streptococcus pneumoniae from the nasopharynx

Infection and Immunity

82(11) 4824-4833
Hambly N, Nair P 2014

Monoclonal antibodies for the treatment of refractory asthma

Current Opinion in Pulmonary Medicine

20(1) 87-94
Nataraj RTY,Cockcroft DW, Fladeland DA. 2014

An uncommon cause of wheeze

Journal of Allergy and Clinical Immunology: In Practice

2(5) 616-617
Davis BE, Stewart SL, Martin AL, Cockcroft DW. 2014

Low levels of fractional exhaled nitric oxide and deep inhalation bronchoprotection are associated with mannitol non-responsiveness in asthma

Respiratory Medicine

108(6) 859-864
Cockcroft DW 2015

Methacholine challenge. PD20 versus PC20

Annals of the American Thoracic Society

12(3) 291-2
Bousquet J, et al. 2015

MACVIA-ARIA Sentinel Network for allergic rhinitis (MASK-rhinitis): The new generation guideline implementation


Cos C, Kjarsgaard M, Cox G, Surette MC, Nair P. 2015

A multi-dimensional approach to the management of severe asthma: inflammomentry, molecular microbiology and bronchial thermoplasty

Canadian Respiratory Journal

22(4) 221-224
Wang H, Dasgupta A, Lee KA, Cook RJ, Nair P. 2015

Changing patterns of Sputum Cell Counts During Successive Exacerbations of Chronic Obstructive Pulmonary Disease


Smith SG, Chen R, Kjarsgaard M, Huang C, Oliveria JP, O'Byrne P, Gauvreau G, Boulet L-P, Lemiere C, Martin JG, Nair P, Sehmi R. 2015

Increased Numbers of Activated Group 2 Innate Lymphoid Cells in the Airways of Severe Asthmatics with Persistent Airway Eosinophilia

Journal of Allergy & Clinical Immunology

Nishioka M, Venkatesan N, Dessalle K, Mogas A, Kyoh S, Lin TY, Nair P, Baglole CJ, Eidelman DH, Ludwig MS, Hamid Q. 2015

Fibroblast-epithelial cell interactions drive epithelial-mesenchymal transition differently in cells from normal and COPD patients

Respiratory Research

Sheridan JA, Zago M, Nair P, Li PZ, Bourbeau J, Tan WC, Hamid Q, Eidelman DH, Benedetti AL, Baglole CJ. 2015

Decreased expression of the NF-kB family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression

Respiratory Research

Chu DK, Al-Garawi A, Llop-Guevara A, Pillai RA, Radford K, Shen P, Walker TD, Goncharova S, Calhou WJ, Nair P, Jordana M. 2015

Therapeutic potential of anti-IL-6 therapies for granulocytic airway inflammation in asthma

Allergy, Asthma & Clinical Immunology

Ellis A, Soliman M, Steacy L, Boulay M, Boulet L, Keith P, Vliagoftis H, Waserman S, Neighbour H 2015

The Allergic Rhinitis – Clinical Investigator Collaborative (AR-CIC): nasal allergen challenge protocol optimization for studying AR pathophysiology and evaluating novel therapies

Allergy, Asthma & Clinical Immunology

Boulet LP, Gauvreau GM, Cockcroft DW, Davis B, Vachon L, Cormier Y, O'Byrne PM 2015

Effects of ASM-024, a modulator of acetylcholine receptor function, on airway responsiveness and allergen-induced responses in patients with mild asthma

Canadian Respiratory Journal

22(4) 230-234
Boulet LP, Gauvreau G, Boulay ME, O'Byrne P, Cockcroft DW 2015

Allergen-induced early and late asthmatic responses to inhaled seasonal and perennial allergens

Clinical & Experimental Allergy

45(11) 1647-53
Boulet L-P, O'Byrne PM. 2015

Asthma and Exercise-Induced Bronchoconstriction in Athletes

The New England Journal of Medicine

372 641-648
Cockcroft DW, Davis BE, Roh Y, Lourens JA 2015

Effect of ingested H1 antihistamines on methacholine challenge

Journal of Allergy and Clinical Immunology

135(2) 579-580
Gauvreau GM, Boulet LP, Leigh R, Cockcroft DW, Killian KJ, Davis BE, Deschesnes F, Watson RM, Swystun V, Mårdh CK, Wessman P, Jorup C, Aurivillius M, O'Byrne PM 2015

A nonsteroidal glucocorticoid receptor agonist inhibits allergen-induced late asthmatic responses

American Journal of Respiratory and Critical Care Medicine

191(2) 161-167
Kwofie K, Scott M, Rodrigues R, Guerette 2015J, Radford K, Nair P, Richards CD 2015

Regulation of IL-17A responses in human airway smooth muscle cells by Onostatin M

Respiratory Research

16(1) 14
Li JJ, Tay HL, Maltby S, Xiang Y, Eyers F, Hatchwell L, Zhou H,  Toop HD, Morris JC,Nair P, Mattes J, Foster PS, Yang M 2015

MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity

Journal of Allergy and Clinical Immunology

in press
Brannan JD, Bood J, Alkhabaz A, Balgoma D, Otis J, Delin I,Dahlén B, Wheelock CE, Nair P, Dahlén SE, O'Byrne PM 2015

The effect of omega-3 fatty acids on bronchial hyperresponsiveness, sputum eosinophilia and mast cell mediators in asthma


147(2) 397-405
Nair P, Aziz-ur-Rehman A, Radford K 2015

Therapeutic implications of neutrophilic asthma

Current Opinion in Pulmonary Medicine

21(1) 33-38
Olfert J, Gjevre J,Cockcroft D. 2015

A nonallergic mechanism for nut-induced wheeze

Journal of Allergy and Clinical Immunology: In Practice

3(1) 108-109
Davis BE, Amakye DO, Cockcroft DW 2015

Airway responsiveness to mannitol 24 hours after 7b allergen challenge in atopic asthmatics


7 pages
Lim HF, Nair P 2015

Efficacy and safety of reslizumab in patients with moderate to severe eosinophilic asthma

Expert Review of Respiratory Medicine

9(2) 135-42
Janssen LJ, Gauvreau GM, Killian KJ, O'Byrne PM 2015

The Effects of Repeated Bronchoprovocation on FEV1 in Subjects with Asthma

Annals of the American Thoracic Society

12(10) 1589-91
Baatjes AJ, Smith SG, Dua B, Watson R, Gauvreau GM, O'Byrne PM 2015

Treatment with anti-OX40L or anti-TSLP does not alter the frequency of T regulatory cells in allergic asthmatics


70(11) 1505-8
Salter BM, Oliveria JP, Nusca G, Smith SG, Watson RM, Comeau M, Sehmi R, Gauvreau GM 2015

Thymic stromal lymphopoietin activation of basophils in patients with allergic asthma is IL-3 dependent

Journal of Allergy and Clinical Immunology

136(6) 1636-44
El-Gammal AI, Killian KJ, Scime TX, Beaudin S, Schlatman A, Cockcroft DW, Gauvreau GM 2015

Comparison of the provocative concentration of methacholine causing a 20% fall in FEV1 between the AeroEclipse II breath-actuated nebulizer and the wright nebulizer in adult subjects with asthma

Annals of the American Thoracic Society

12(7) 1039-43
Watson BM, Oliveria JP, Nusca GM, Smith SG, Beaudin S, Dua B, Watson RM, Assayag EI, Cormier YF, Sehmi R, Gauvreau GM 2015

Inhibition of allergen-induced basophil activation by ASM-024, a nicotinic receptor ligand

International Archives of Allergy and Immunology

165(4) 255-64
Smith SG, Gugilla A, Mukherjee M, Merim K, Irshad A, Tang W, Kinoshita T, Watson B, Oliveria JP, Comeau M, O'Byrne PM, Gauvreau GM, Sehmi R 2015

Thymic stromal lymphopoietin and IL-33 modulate migration of hematopoietic progenitor cells in patients with allergic asthma

Journal of Allergy and Clinical Immunology

136(5) 1594-602
Zuccaro L, Cox A, Pray C, Radford K, Novakowski K, Dorrington M, Surette M, Bowdish D, Nair P 2016

Histone deacetylase activity and recurrent neutrophilic bronchitis in severe eosinophilic asthma


71(4) 571-575
Gauvreau GM, Boulet LP, Leigh R, Cockcroft DW, Davis BE, Mayers I et al. 2016

Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting the allergen-induced early asthmatic response

Journal of Allergy and Clinical Immunology

Aleman F, Lim HF, Nair P 2016

Eosinophilic Endotype of Asthma

Immunology and Allergy Clinics of North America

36(3) 559-568
Mukherjee M, Nair P 2016

Blood or sputum eosinophils to guide asthma therapy?

The Lancet Respiratory Medicine

Mitchell PD, Salter BM, Oliveria JP, El-Gammal A, Tworek D, Smith SG, Sehmi R, Gauvreau GM, Butler M, O'Byrne PM 2016

Glucagon Like Peptide-1 receptor expression on human eosinophils and its regulation of eosinophil activation

Clinical and Experimental Allergy

Tang W, Smith SG, Salter B, Oliveria JP, Mitchell P, Nusca GM, Howie K, Gauvreau GM, O'Byrne PM, Sehmi R 2016

Allergen-Induced Increases in Interleukin-25 and Interleukin-25 Receptor Expression in Mature Eosinophils from Atopic Asthmatics

International Archives of Allergy and Immunology

170(4) 234-242
Todd CM, Salter BM, Murphy DM, Watson RM, Howie KJ, Milot J, Sadeh J, Boulet LP, O'Byrne PM, Gauvreau GM 2016

The effects of a CXCR1/CXCR2 antagonist on neutrophil migration in mild atopic asthmatic subjects

Pulmonary Pharmacology and Therapeutics

Salter BM, Manzoor F, Beaudin S, Kjarsgaard M, Nair P, Gauvreau GM, Sehmi R 2016

Dysregulation of Vascular Endothelial Progenitor Cells Lung-Homing in Subjects with COPD

Canadian Respiratory Journal

Gauvreau GM, Boulet LP, FitzGerald JM, Cockcroft DW, Davis BE, Leigh R, Tanaka M, Fourre JA, Tanaka M, Nabata T, O'Byrne PM 2016

A dual CysLT1/2 antagonist attenuates allergen-induced airway responses in subjects with mild allergic asthma


71(12) 1721-7
El-Gammal A, Oliveria JP, Howie K, Watson R, Mitchell P, Chen R, Baatjes A, Smith S, Al-Sajee D, Hawke TJ, Killian KJ, Gauvreau GM, O'Byrne PM 2016

Allergen-induced Changes in Bone Marrow and Airway Dendritic Cells in Subjects with Asthma

American Journal of Respiratory and Critical Care Medicine

194(2) 169-77
Salter BM, Oliveria JP, Nusca G, Smith SG, Tworek D, Mitchell PD, Watson RM, Sehmi R, Gauvreau GM 2016

IL-25 and IL-33 induce Type 2 inflammation in basophils from subjects with allergic asthma

Respiratory Research

Tworek D, Smith SG, Salter BM, Baatjes AJ, Scime T, Watson R, Obminski C, Gauvreau GM, O'Byrne PM 2016

IL-25 Receptor Expression on Airway Dendritic Cells after Allergen Challenge in Subjects with Asthma

American Journal of Respiratory and Critical Care Medicine

193(9) 957-64
Salter BM, Nusca G, Tworek D, Oliveria JP, Smith SG, Watson RM, Scime T, Obminski C, Sehmi R, Gauvreau GM 2016

Expression of activation markers in circulating basophils and the relationship to allergen-induced bronchoconstriction in subjects with mild allergic asthma

Journal of Allergy and Clinical Immunology

137(3) 936-8