​Study finds protein difference in lungs of asthmatics

rr-logoSurfactant protein D (SP-D) is an important molecule in the lungs that protects lung cells from inhaled pollutants, microbes and allergens.

In a new study published in Respiratory Research, AllerGen researchers report that SP-D in asthmatics differs from that found in non-asthmatics, and that this difference can influence a person’s susceptibility to infections and result in an altered inflammatory response in asthmatic patients.

The study also showed that SP-D protein expression in asthmatics compared to non-asthmatics differed in response to IL-13, a cytokine closely associated with allergic asthma. This regulation difference may be a cause of the higher infection and exacerbation incidence in asthmatics.

The research team included AllerGen investigator Dr. Delbert Dorscheid and AllerGen trainees Drs Gurpreet Singhera and Jie Xu.

Posted in Investigator news, Publications/Research updates